Malaria is one of the world's biggest solvable problems, annually killing over 400K people. Many countries eliminated it decades ago via massive treatment of stagnant water bodies. However, similar attempts in Sub-Saharan Africa have generally failed to detect and treat a sufficient percentage of often small water bodies. Zzapp has developed an artificial intelligence-based system for planning, executing, and monitoring of large-scale, cost-effective malaria elimination campaigns. It has been working in several countries, providing protection for more than 200K people, and is now launching an operation in São Tomé and Príncipe to fully eliminate the disease–if successful, this will be an unprecedented achievement in Sub-Saharan Africa.